Liu and colleagues have developed an innovate technique to engraft differentiated muscle tissue into subcutaneous space. The muscle graft contracts automatically and promotes systemic health benefits of exercise in the setting of aging and obesity. Benefits include preservation of lean mass and enhanced whole-body metabolic function
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Subjects
- Medical research
- Physiology
References
Strain, T. et al. Lancet Glob. Health12, e1232–e1243 (2024)
Liu, X. et al. Nat. Aginghttps://doi.org/10.1038/s43587-026-01190-3 (2026)
Rao, L. et al. Nat. Commun.9, 126 (2018)
Pojednic, R. et al. Int. J. Environ. Res. Public Health19, 4981 (2022)
Sousa-Victor, P. et al. Nature506, 316–321 (2014)
White, J. P. et al. Stem Cell Rep.11, 425–439 (2018)
Kraus, W. E. et al. Med. Sci. Sports Exerc.51, 1270–1281 (2019)
Febbraio, M. A. et al. Diabetes53, 1643–1648 (2004)
Trinh, B. et al. Cell Rep. Med.2, 100396 (2021)
Mathur, N. & Pedersen, B. K. Mediators Inflamm.2008, 109502 (2008)
Crane, J. D. et al. Aging Cell14, 625–634 (2015)
Vinel, C. et al. Nat. Med.24, 1360–1371 (2018)
Rao, R. R. et al. Cell157, 1279–1291 (2014)
Bostrom, P. et al. Nature481, 463–468 (2012)
Islam, M. R. et al. Nat. Metab.3, 1058–1070 (2021)
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Department of Medicine, Duke University, Durham, NC, USA
James P. White
Duke Aging Centre, Duke University, Durham, NC, USA
James P. White
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White, J.P. Contracting myografts mimic exercise response.
Nat Aging (2026). https://doi.org/10.1038/s43587-026-01191-2
Published:26 August 2026
Version of record:26 August 2026
DOI
:https://doi.org/10.1038/s43587-026-01191-2


