Browsing: glioblastoma

Nutrition

Low carbohydrate high fat diet curbs glioblastoma by shifting lipids and limiting cancer stem cell metabolic flexibility

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Metabolic rewiring fuels tumorigenicity of cancer stem cells contributing to universal glioblastoma (GBM) recurrence. Invasive glioblastoma stem cells (GSCs), already unresectable, acquire tumorigenic properties that confer therapy resistance. Using samples from both recurrent and newly diagnosed GBM patients, we identified fatty acid oxidation (FAO) as a key pathway supporting GSC tumorigenicity. Transcriptomic profiling, compared against…