Browsing: Succinate

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Succinate exacerbates obesity-associated osteoarthritis: mitochondrial dysfunction mediated by SUCNR1 activation and succinylation modification

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Osteoarthritis (OA) is the most prevalent degenerative joint disease and is closely related to obesity. The molecular mechanisms underlying obesity-induced metabolic alterations that lead to cartilage degeneration have not been fully elucidated. Succinate, a key intermediate in the Krebs cycle, exhibits signaling functions that extend beyond its traditional metabolic role. This study demonstrates that succinate…