Oxygen relief for a proteostasis-driven disease associated with mitochondrial complex I dysfunction

Hypoxia has emerged as an unexpected therapy for some mitochondrial diseases. Garg et al. now extend this concept beyond primary respiratory chain mutations, showing that reducing oxygen tension can rescue a disease of mitochondrial protein quality control linked to the HTRA2–CLPB axis

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Acknowledgements

A.S.G. is supported in part by the National Institute on Aging (R01AG084718)

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1. Department of Chemistry, University of Cincinnati, Cincinnati, OH, USA

   Anthony S. Grillo

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1. Anthony S. GrilloView author publications

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Grillo, A.S. Oxygen relief for a proteostasis-driven disease associated with mitochondrial complex I dysfunction.
Nat Metab (2026). https://doi.org/10.1038/s42255-026-01569-x

• Published:08 July 2026

• Version of record:08 July 2026

• DOI
  :https://doi.org/10.1038/s42255-026-01569-x