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For decades, obesity has posed one of the most formidable threats to public health. Individuals living with obesity are at heightened risk of myriad co-morbid conditions, ranging from cardiovascular disease and type 2 diabetes to certain cancers. Given the expansive health implications of obesity, its prevention and treatment are critical to improving population health outcomes.…

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Obesity is a serious multifactorial disease that involves epigenetic mechanisms like DNA methylation. Tyrosine kinase inhibitors (TKIs), originally synthesized and approved for cancer therapy, have recently been linked to the regulation of obesity. We evaluated whether LPM4870108, a small-molecule TKI with antitumor efficacy, contributes to obesity

Rare and undiagnosed diseases pose diagnostic challenges due to phenotypic and genetic heterogeneity and the limitations of conventional molecular testing. As part of the RareBoost project, we implemented an integrated, stepwise genomic strategy in a cohort of 134 patients from 120 families with previously inconclusive genetic testing. Our strategy combined systematic exome sequencing with subsequent…