Browsing: intestinal

CROHN’S disease monocytes showed systemic transcriptional and functional reprogramming that may contribute to intestinal inflammation, according to data from newly diagnosed, treatment-naïve patients. 

Long-term high-fat diet (HFD) leads to metabolic disorders and disrupts intestinal immune regulation. Zeaxanthin, a bioactive carotenoid known for antioxidant and immunomodulatory effects, has limited evidence regarding its role in obesity-triggered gut immune dysfunction. This study investigated zeaxanthin’s effects on intestinal barrier function, immune homeostasis, and metabolic profiles in HFD-induced obese mice. Results showed that…

The gut constantly interacts with both pathogens and dietary signals, but how it balances immune and metabolic responses remains unclear. Here we show that intestinal cGAS, a key DNA sensor, acts as a regulator linking gut immunity to whole-body metabolism. We show that cGAS signalling is activated in the intestines of humans and male mice…

Diet composition shapes tissue function and disease risk by modulating nutrient availability, metabolic state and cellular dynamics1. In the gastrointestinal tract, obesogenic high-fat diets enhance small-intestinal stem cell activity and tumorigenesis2. However, the impact of ketogenic diets (KDs), which contain even higher lipid content but reduce circulating insulin and induce ketogenesis, remains poorly understood3. This…

The Centers for Disease Control and Prevention offices in Atlanta are seen in 2022. The agency is investigating a rise in cyclosporiasis cases. Ron Harris/APhide caption

Texas is one of at least 17 states currently being affected by a parasite known as Cyclospora, which can cause digestive issues