Browsing: Mitochondrial

Osteoarthritis (OA) is the most prevalent degenerative joint disease and is closely related to obesity. The molecular mechanisms underlying obesity-induced metabolic alterations that lead to cartilage degeneration have not been fully elucidated. Succinate, a key intermediate in the Krebs cycle, exhibits signaling functions that extend beyond its traditional metabolic role. This study demonstrates that succinate…

Mitochondria are essential for cellular homeostasis, integrating various signals to control key cellular functions such as metabolism, apoptosis, inflammation, cell proliferation and redox balance. Given their multifaceted functions, it is not surprising that mitochondrial dysfunction has been implicated as a key contributor to the pathogenesis of numerous human diseases. Consequently, preserving mitochondrial integrity and functionality…

Consumers are looking to supplements to help support “healthspan” — the years of life lived in good health and vitality — according to a new report published by Industry Transparency Centre (ITC)