Watch:Why Chrissy Metz Finally Said Yes to a GLP-1 After Being a “Skeptic” for Years
Chrissy Metz is getting candid about a recent breakthrough
Amid her years-long <a href="https://healthylife7.com/death-of-law-student-linked-to-popular-weight-loss-shot/" title="Death of law student linked to popular weight loss shot”>weight loss journey, the Breakthrough actress shared that she decided to start using GLP-1s—type 2 diabetes medications that are also prescribed for weight loss—despite being hesitant about them in the past.
“I was very skeptical of starting a GLP-1 for a very long time,” Metz exclusively told E! News while discussing her partnership with Ro, a telehealth company that provides online evaluations and home treatment delivery. “I’m talking probably six years, since really COVID, when people were sort of talking about it. I’m just very diligent about what and how things work within the body, and I’m like, ‘Oh, I don’t know what that’s gonna be like.’”
So, what changed her mind? After a friend conducted “very thorough” research on the medications—which include common brand names Ozempic, Mounjaro, Wegovy and more—and Metz dove into her own family health history, she realized GLP-1s “might be something I should look into.”
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“I’ve been on diets for a very, very long time, since I was a kid, and I know I can lose weight,” she explained, “but I didn’t know that I could quiet food noise and I didn’t know there were other factors. There’s so much shame around being in a bigger body, so just knowing that I wasn’t doing it purely for vanity’s sake, but because people are pressuring me, or I should, or shouldn’t, do that.”
TheThis Is Us alum recalled asking herself: “How can I be the healthiest for the longest? How can I really make it a priority for my future and what I want my life to look like?”
And now, after making the decision to start a GLP-1 through Ro, which also includes Serena Williams among its celebrity ambassadors, Metz emphasized that the medication has positively impacted her health, including how she feels performing on Broadway in & Juliet eight times a week
“It’s helped with inflammation. It’s helped with just overall health lab work and blood work,” she shared, “and just generally just an overall feeling of space and creativity that the food noise has quieted. It opens up just more ability to be present and for me to be more creative and to really spend my time—my mind time, as I say—with the show and not obsessing about food noise that I didn’t even know was a thing, which is crazy.”
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While she emphasized that people are going to have “opinions” about her body no matter what, the 45-year-old shared that she hopes her being “vulnerable” about her GLP-1 journey inspires others to make choices for themselves despite what others may say
“I hope that it really opens up conversation,” Metz shared, “because I think there are people who, not even with medication, but want to try things in their life, but are afraid of what people are going to say, and don’t do it, and perhaps don’t find the life that they want, or the joy that they want or deserve because we’re so transfixed on what people think about our choices.”
As she emphasized, “Again, I was the biggest skeptic. I was like, ‘No, no, no, no, no.’ So, I hope it enlightens people to an option that might be right for them.”
For a closer look at what other stars had to say about their experience with weight loss medications, keep reading…
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They each opted to get on the lowest dose possible of Monjaro, combining the shots with exercise and balanced meals. “Daryl and I both do everything together,” the “All About That Bass” singer explained. “And we started that journey.”
“I have a secret sauce,” she said on YouTube in Janaury 2023. “It’s killing the fat and I’m just peeing it out. At least, that’s how I understand it.”
“I decided then that after the medical issue, I was going to get a colonoscopy,” Jonathan said in a TikTok video, “and if I didn’t have anything severely wrong with me, I was going to go on a GLP-1, because I just didn’t feel good.”
They added, “As I’ve lost weight and I got into [Pilates classes at] Solidcore, my body has never looked like this,” Jonathan said. “My body’s never in my whole life—I’ve always wanted to have an ab. I’ve never had abs. And I feel really good, so I’m taking my shirt off a lot.”
Despite losing 70 pounds with the help of the drug, Jonathan re-emphasized their stance on body positivity.
“I’m all about body neutrality,” they continued. “The way that you look does not define your worth, doesn’t define your lovableness. You are worth love and worth celebration no matter what your body looks like.”
“I cant believe this is me now,” Rosie wrote on her Instagram, “#mounjaro #weightloss #bodydismorphia.”
However, she resumed what she called her “GLP-1 journey” in March 2026, writing on Instagram that she was “being really intentional” about her usage this time around.
“For me, it wasn’t just about weight… it was about feeling better, having more energy, and actually trusting the process instead of rushing it,” she continued. “I wanted something that felt transparent, supportive, and realistic for my lifestyle.”
“I love it. I’m like, ‘Do it,’” she said on The Tonight Show Starring Jimmy Fallon. “I have no judgment. If you want to do Ozempic, hell yeah, girl.”
She added, “I want people to feel more comfortable talking about doing it, because I feel like there’s this shame,” she continued. “The shame is only from thin people who want you to stay fat. That’s really where it’s coming from. They’re so mad that you’re getting thin now, because that’s all they have, right? You’re dynamic, you have a good personality, and they’re so mad.”
“I took, like, a little bit when it first came out, and everyone was doing it,” Nader told Us Weekly. “It made me really nauseous. I liked it—I am not going to lie—and when I went on Dancing with the Stars, I could not do both.”
Brooks said she “lost a little bit of the motivation and the strength to work out” by taking the medication. “It was one or the other,” she said, “and I picked dancing. I put the shot away.”
But before finding the solution that works for her, she had a rough go with Ozempic. “I hated it,” she revealed to E! News. “I could not eat without feeling nauseous. I could not eat at all, sometimes. My body did not like it.”
“I think that when you’re in reality TV, it’s so natural to be like, ‘Oh, she got plastic surgery or she did this or she’s on Ozempic,’” she told Us Weekly in October 2024. “I actually f–king hate Ozempic. I would never put needles in myself.”
Later, though, the musician admitted she gave some injectibles a shot.
“I tried everything,” Lizzo told host Trisha Paytas during a June 2025 episode of the Just Trish podcast, before explaining why she wound up ditching GLP-1 medications early on in her journey. “Ozempic works because you eat less food, yeah? So if you eat right, it makes you feel full. But if you can just do that on your own and get mind over matter, it’s the same thing.”
After taking a dosage meant for those roughly 220 pounds or more, the model was struggling to keep any food or water down and landed in the emergency room.
“I literally had a seizure from how dehydrated I was, which honestly was the scariest thing that’s ever happened to me in my life,” she admitted. “My friend had to hold my feet down. It was so scary, the whole situation. My face was clenching up, my whole body was tense.”
“You know what’s annoying?” he said. “The regret of not starting it 10 years ago.”
She added, “But you’ll never hear a second of judgment from me about people who choose that direction!”
In March 2024, his health journey appeared to take a surprising turn. “I’ve learned to out-eat Ozempic,” he said on The Tonight Show Starring Jimmy Fallon. “I gained 40 pounds.”
Later that month, he clarified to E! News that he was joking, adding, “Ozempic did great by me and I was glad to use it.”
“After 40, we all know it’s very, very hard to lose weight,” she said in the May 22 episode of her podcast Uncut & Uncensored With Caroline Stanbury. “But I met so many 40-year-old women going, ‘How have you done it?’ And I don’t want to lie to you, I used Ozempic, which I think is one of the best tools if you’re able to use it.”
“It didn’t curb my appetite. I know some people are like, ‘Oh, I can’t eat.’ Not me! I was eating appetizers, a regular meal and dessert, okay? It didn’t stop anything for me,” she shared in June 2024. “When you see it worked for other people and it doesn’t work for you, it makes you depressed. Realistically, it makes you feel like, ‘What is wrong with me? Why is it not working for me?'”
“I have a daily battle with myself not to go on Ozempic,” Jade told The Guardian in August 2025. “I don’t judge people that do, but because I have a history of eating disorders, I don’t know where taking something like that would end for me.”
“I tried Ozempic and it didn’t work for me,” she shared in an April 2024 episode of her misSPELLING podcast, “so I went on Mounjaro, which did do the trick and I did lose weight.”
Raven continued, “Do what you gotta do, just make sure you save the medication for the people who actually need it.”
“Whatever you choose is up to you,” she exclusively told E! News. “It’s not a dirty little secret when you’ve taken something to help you lose weight, which is perfectly fine.”
She added, “We don’t have to bulls–t.”
“I think it’s amazing,” the Fashion Police alum told E! News in January 2024. “There are a million ways to lose weight, why not do it through something that isn’t as boring as working out?”
“I actually don’t know what Ozempic is,” Kate admitted to The New York Times Magazine in an interview published in March 2024. “All I know is that it’s some pill that people are taking or something like that.”
“Oh, my God,” Kate remarked after learning about the injectable. “This sounds terrible.”
Heidi noted, “I want something that is sustainable. I want something that does also require hard work.”
“Everyone and their mom is gonna try it. Everyone has been lying saying, ‘Oh, smaller portions,'” she told Andy Cohen, who has also publicly weighed in on the Ozempic craze multiple times. “Like, shut the f–k up. You are on Ozempic or one of those things, or you got work done. Just stop.”
Schumer, who has been open about her past medical procedures, added, “Be real with people. When I got lipo, I said I got lipo.”
She admitted to becoming “immediately invested” in Ozempic in 2022, but explained that it was not “livable” for her to take the Type 2 diabetes drug as it hindered her ability to spend time with her son Gene.
“I was one of those people that felt so sick and couldn’t play with my son,” Schumer recalled. “I was so skinny, and he’s throwing a ball at me and [I couldn’t].”
He continued, “If we have a medication that can be helpful, by all means, people should be encouraged to think about it.”
The Game of Thrones alum was not shy when it came to sharing her opinion about Ozempic and its advertisements.
In an April 5, 2023 Instagram Story, the actress reposted a tweet from writer Sophie Vershbow that read, “The Ozempic ads plastered across the Times Square subway station can f–k all the way off.” One ad featured in Vershbow’s Twitter photos read, “One shot to lose weight,” while another offered similar text, “A weekly shot to lose weight.”
Turner adding her own commentary, writing, “WTF.”
Ozempic maker Novo Nordisk previously told E! News that the drug is not FDA-approved for chronic weight management.
“While we recognize that some healthcare providers may be prescribing Ozempic for patients whose goal is to lose weight, Novo Nordisk does not promote, suggest, or encourage off-label use of our medicines and is committed to fully complying with all applicable U.S. laws and regulations in the promotion of our products,” the Danish pharmaceutical company said in a statement. “We trust that healthcare providers are evaluating a patient’s individual needs and determining which medicine is right for that particular patient.”
“I didn’t even know I was on it,” she said during the Jan. 25, 2023 episode of Call Her Daddy. “She said, ‘If you ever want to drop five pounds, this is good.'”
But while she tried the drug, Handler noted that she didn’t like how it made her feel.
“I came back from a vacation and I injected myself with it,” she recalled. “I went to lunch with a girlfriend a few days later, and she was like, ‘I’m not really eating anything. I’m so nauseous, I’m on Ozempic.’ And I was like, ‘I’m kind of nauseous too.’ But I had just come back from Spain and was jet-lagged.”
Ultimately, Handler stopped using the drug because it wasn’t medically necessary for her, adding that she gave away the remaining doses to friends.
“I’ve injected about four or five of my friends with Ozempic, because I realized I didn’t want to use it because it was silly,” she said. “It’s for heavy people. I have people coming over to my house, and I’m like, ‘OK, I can see you at 1, I can see you at 2.'”
“Let’s not discredit my years of working out,” Kardashian wrote on a January 2023 post. “I get up 5 days a week at 6am to train. Please stop with your assumptions. I guess new year still means mean people.”
View More Photos From Celebrities Speaking Out on Ozempic and Weight Loss Medications
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