Browsing: Wellness Tips

Obesity is a major risk factor for colorectal cancer (CRC), yet the mechanisms linking obesity-associated gut dysbiosis to tumor progression remain unclear. Here, we show that a high-fat diet and fecal microbiota from patients with obesity-associated CRC deplete the GABA-producing commensal Bacteroides ovatus, resulting in reduced luminal GABA and accelerated tumorigenesis. Microbial GABA activates epithelial…

NEW real-world evidence shows that GLP-1 receptor agonists significantly reduce joint pain and inflammation in psoriatic arthritis. Patients living with psoriatic arthritis frequently experience a heavy metabolic disease burden, with concomitant obesity operating as a primary driver of heightened systemic inflammation, severe disease activity, and reduced response to biological therapies. To evaluate the therapeutic potential…