However, chronic kidney disease is increasingly associated with diabetes and heart failure.
(HealthDay News) — Chronic kidney disease (CKD) is increasingly associated with diabetes, according to a research letter published online July 8 in the New England Journal of Medicine
Sophie E. Claudel, M.D., from the Boston Medical Center, and Ashish Verma, M.B.B.S., from Boston University, examined contemporary national trends in CKD prevalence. The analysis included data for 25,106 adults (20 years of age and older) who participated in four cycles of the National Health and Nutrition Examination Survey from 2013-2014 to 2021-2023
The researchers found that the prevalence of CKD was generally stable between 2013-2014 (14.5 percent) and 2021-2023 (14.8 percent), corresponding to an estimated 36 million adults. Throughout the study period, a greater proportion of adults met criteria based on albuminuria alone than on a low estimated glomerular filtration rate (eGFR) alone (8.6 versus 4.1 percent in 2021-2023). There was variance in the prevalence of CKD by demographic characteristics and comorbidity burden, with a higher prevalence among Black adults and those living below the federal poverty threshold. Over time, the burden of CKD with diabetes increased from 4.7 percent in 2013-2014 to 5.7 percent in 2021-2023 (prevalence ratio, 1.29), with no change in the prevalence of CKD without diabetes. There was also a strong association between heart failure and prevalent CKD, with this association peaking in the 2021-2023 cycle (adjusted prevalence ratio, 2.47), surpassing obesity (adjusted prevalence ratio, 1.35) and rivaling diabetes (adjusted prevalence ratio, 2.49) as the coexisting condition most strongly associated with CKD.
“This is the first CKD study to utilize the recently released survey data spanning a decade, encompassing the period during which the first therapies specifically approved to protect the kidneys, namely SGLT2 inhibitors and finerenone (a nonsteroidal mineralocorticoid receptor antagonist that mitigates the risk of kidney failure), were introduced into the market. Remarkably, despite these advancements, overall CKD rates have remained stagnant,” Verma said in a statement
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