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    Home»Conditions»Binge-eating behavior and anorexia nervosa have shared and distinct genetic components
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    Binge-eating behavior and anorexia nervosa have shared and distinct genetic components

    healthylife7By healthylife7August 19, 2026No Comments2 Mins Read
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    Binge-eating behavior and anorexia nervosa have shared and distinct genetic components
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    Genome-wide association studies of individuals with binge-eating behavior, anorexia nervosa or neither identify distinct genetic associations with each phenotype. Although both eating disorder phenotypes correlate genetically with other psychiatric conditions, binge eating also correlates with impulsivity, earlier age at first menstrual cycle and increased body mass, whereas anorexia nervosa shares genetics with metabolic traits

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    Fig. 1: Genetic correlations of eating phenotypes.

    Subjects

    • Genome-wide association studies
    • Psychiatric disorders

    References

    1. Solmi, M. et al. Outcomes in people with eating disorders: a transdiagnostic and disorder-specific systematic review, meta-analysis and multivariable meta-regression analysis. World Psychiatry23, 124–138 (2024). A comprehensive systematic review of the outcomes of eating disorders

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    2. Grilo, C. M. Treatment of eating disorders: current status, challenges, and future directions. Annu. Rev. Clin. Psychol.20, 97–123 (2024). A narrative review of the current state of treatment for eating disorders

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    3. Watson, H. J. et al. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nat. Genet.51, 1207–1214 (2019). A genome-wide association study from the Eating Disorders Working Group of the Psychiatric Genomics Consortium that examined only AN

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    4. Berthold, N. et al. The Eating Disorders Genetics Initiative 2 (EDGI2): study protocol. BMC Psychiatry25, 532 (2025). The protocol paper for the second Eating Disorders Genetics Initiative, which will expand eating disorders genetics to new disorders and enable the investigation of additional shared symptoms

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    Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations

    This is a summary of: Termorshuizen, J. D. et al. Genomic meta-analyses of binge-eating behavior and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes. Nat. Ment. Healthhttps://doi.org/10.1038/s44220-026-00698-2 (2026)

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    Binge-eating behavior and anorexia nervosa have shared and distinct genetic components.
    Nat. Mental Health (2026). https://doi.org/10.1038/s44220-026-00697-3

    • Published:19 August 2026

    • Version of record:19 August 2026

    • DOI
      :https://doi.org/10.1038/s44220-026-00697-3

    anorexia Behavior Bingeeating have nervosa
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