Watch:Why Chrissy Metz Finally Said Yes to a GLP-1 After Being a “Skeptic” for Years
For more than half a decade, Chrissy Metz was determined to avoid the big three.
As in Ozempic, Mounjaro, Wegovy
Of course, the list of GLP-1 weight loss injectables and the public’s ability to rattle them off has vastly expanded since news of oh-oh-oh Ozempic shot to the top of public consciousness in 2023.
“I was very skeptical of starting a GLP-1 for a very long time,” the actress recently explained in an exclusive interview with E! News. “I’m just very diligent about what and how things work within the body.”
But after listening to a friend’s “very thorough” research, she was ready to give it a shot.
She’d “been on diets for a very, very long time, since I was a kid,” the 45-year-old explained to E!. But she’d never been able to quiet the food noise until she partnered with Ro, the telehealth company Serena Williamsteamed up with when she was determined to ace a weight loss journey of her own.
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Celebrity Weight Loss Transformations
Metz’s motivation wasn’t “doing it purely for vanity’s sake,” she explained, but rather a desire to carve out her own happily ever after.
As she embarked on a three-month Broadway run in & Juliet, the This Is Meauthor recalled asking herself: “‘How can I be the healthiest for the longest?'” she recounted. “‘How can I really make it a priority for my future and what I want my life to look like?'”
And she’s not the only star to learn that parting with her previously held beliefs surrounding weight loss drugs is definitively not sweet sorrow.
Having spent her share of time crying on the kitchen floor over her postpartum wellness journey, Trisha Paytas has been thrilled with the 26 pounds she’s shed using Zepbound.
“We see so many people losing weight and kind of denying being on a GLP-1,” she explained to People in June, “but I just wanna be as transparent as possible so people know why and then other people who have the same issues with food can feel if it’s right for them.”
And they’re just the latest stars to serve up their reasons for trying the medication. Check out who else has weighed in.
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But after listening to a friend’s “very thorough” research, she teamed with telehealth company Ro.
“I’ve been on diets for a very, very long time, since I was a kid, and I know I can lose weight,” she explained, “but I didn’t know that I could quiet food noise and I didn’t know there were other factors. There’s so much shame around being in a bigger body, so just knowing that I wasn’t doing it purely for vanity’s sake.”
Because the result that makes her want to sing its praises is the way it helps her push through eight shows a week in Broadway’s & Juliet.
“It’s helped with inflammation,” she noted. “It’s helped with just overall health lab work and blood work and just generally just an overall feeling of space and creativity that the food noise has quieted. It opens up just more ability to be present.”
“I was starving myself, killing myself in the gym, eating grapefruit for dinner and I just was not losing it,” she recounted to People in June 2026. “And I’ve tried everything else in my life, like all the fad diets, so I was like, ‘OK, I should just try a GLP-1 if it’s working for so many people.'”
Six weeks into her Zepbound journey, she was down 26 pounds and making plans to run 26.2 miles as she considers a 2027 marathon.
“I’ve lived 38 years of my life obsessing about food,” she explained, “it would be nice to live the next 38 just thinking about food a normal amount.”
After a bit of back-and-forth volleying, the Ro partner stuck with a GLP-1 medication that helped her drop 31 pounds.
Sharing her desire to do away with the idea that the medication is a “shortcut,” she explained, “As an athlete and as someone that has done everything, I just couldn’t get my weight to where I needed to be at a healthy place.”
And that wasn’t all that she shared.
“One of the things that I realized the very first time I took a GLP-1 was that all these years I thought that thin people, those people just had more willpower,” she noted. “They ate better foods. They were able to stick to it longer. They never had a potato chip.”
But when she started her regimen, she realized “that, ‘Oh, they’re not even thinking about it. They’re only eating when they’re hungry and they’re stopping when they’re full.'”
They each opted to get on the lowest dose possible of Monjaro, combining the shots with exercise and balanced meals. “Daryl and I both do everything together,” the “All About That Bass” singer explained. “And we started that journey.”
“I have a secret sauce,” she said on YouTube in Janaury 2023. “It’s killing the fat and I’m just peeing it out. At least, that’s how I understand it.”
“I decided then that after the medical issue, I was going to get a colonoscopy,” Jonathan said in a TikTok video, “and if I didn’t have anything severely wrong with me, I was going to go on a GLP-1, because I just didn’t feel good.”
They added, “As I’ve lost weight and I got into [Pilates classes at] Solidcore, my body has never looked like this,” Jonathan said. “My body’s never in my whole life—I’ve always wanted to have an ab. I’ve never had abs. And I feel really good, so I’m taking my shirt off a lot.”
Despite losing 70 pounds with the help of the drug, Jonathan re-emphasized their stance on body positivity.
“I’m all about body neutrality,” they continued. “The way that you look does not define your worth, doesn’t define your lovableness. You are worth love and worth celebration no matter what your body looks like.”
“I cant believe this is me now,” Rosie wrote on her Instagram, “#mounjaro #weightloss #bodydismorphia.”
However, she resumed what she called her “GLP-1 journey” in March 2026, writing on Instagram that she was “being really intentional” about her usage this time around.
“For me, it wasn’t just about weight… it was about feeling better, having more energy, and actually trusting the process instead of rushing it,” she continued. “I wanted something that felt transparent, supportive, and realistic for my lifestyle.”
“I love it. I’m like, ‘Do it,’” she said on The Tonight Show Starring Jimmy Fallon. “I have no judgment. If you want to do Ozempic, hell yeah, girl.”
She added, “I want people to feel more comfortable talking about doing it, because I feel like there’s this shame,” she continued. “The shame is only from thin people who want you to stay fat. That’s really where it’s coming from. They’re so mad that you’re getting thin now, because that’s all they have, right? You’re dynamic, you have a good personality, and they’re so mad.”
“I took, like, a little bit when it first came out, and everyone was doing it,” Nader told Us Weekly. “It made me really nauseous. I liked it—I am not going to lie—and when I went on Dancing with the Stars, I could not do both.”
Brooks said she “lost a little bit of the motivation and the strength to work out” by taking the medication. “It was one or the other,” she said, “and I picked dancing. I put the shot away.”
But before finding the solution that works for her, she had a rough go with Ozempic. “I hated it,” she revealed to E! News. “I could not eat without feeling nauseous. I could not eat at all, sometimes. My body did not like it.”
“I think that when you’re in reality TV, it’s so natural to be like, ‘Oh, she got plastic surgery or she did this or she’s on Ozempic,’” she told Us Weekly in October 2024. “I actually f–king hate Ozempic. I would never put needles in myself.”
Later, though, the musician admitted she gave some injectibles a shot.
“I tried everything,” Lizzo told host Trisha Paytas during a June 2025 episode of the Just Trish podcast, before explaining why she wound up ditching GLP-1 medications early on in her journey. “Ozempic works because you eat less food, yeah? So if you eat right, it makes you feel full. But if you can just do that on your own and get mind over matter, it’s the same thing.”
After taking a dosage meant for those roughly 220 pounds or more, the model was struggling to keep any food or water down and landed in the emergency room.
“I literally had a seizure from how dehydrated I was, which honestly was the scariest thing that’s ever happened to me in my life,” she admitted. “My friend had to hold my feet down. It was so scary, the whole situation. My face was clenching up, my whole body was tense.”
“You know what’s annoying?” he said. “The regret of not starting it 10 years ago.”
She added, “But you’ll never hear a second of judgment from me about people who choose that direction!”
In March 2024, his health journey appeared to take a surprising turn. “I’ve learned to out-eat Ozempic,” he said on The Tonight Show Starring Jimmy Fallon. “I gained 40 pounds.”
Later that month, he clarified to E! News that he was joking, adding, “Ozempic did great by me and I was glad to use it.”
“After 40, we all know it’s very, very hard to lose weight,” she said in the May 22 episode of her podcast Uncut & Uncensored With Caroline Stanbury. “But I met so many 40-year-old women going, ‘How have you done it?’ And I don’t want to lie to you, I used Ozempic, which I think is one of the best tools if you’re able to use it.”
“It didn’t curb my appetite. I know some people are like, ‘Oh, I can’t eat.’ Not me! I was eating appetizers, a regular meal and dessert, okay? It didn’t stop anything for me,” she shared in June 2024. “When you see it worked for other people and it doesn’t work for you, it makes you depressed. Realistically, it makes you feel like, ‘What is wrong with me? Why is it not working for me?'”
“I have a daily battle with myself not to go on Ozempic,” Jade told The Guardian in August 2025. “I don’t judge people that do, but because I have a history of eating disorders, I don’t know where taking something like that would end for me.”
“I tried Ozempic and it didn’t work for me,” she shared in an April 2024 episode of her misSPELLING podcast, “so I went on Mounjaro, which did do the trick and I did lose weight.”
Raven continued, “Do what you gotta do, just make sure you save the medication for the people who actually need it.”
“Whatever you choose is up to you,” she exclusively told E! News. “It’s not a dirty little secret when you’ve taken something to help you lose weight, which is perfectly fine.”
She added, “We don’t have to bulls–t.”
“I think it’s amazing,” the Fashion Police alum told E! News in January 2024. “There are a million ways to lose weight, why not do it through something that isn’t as boring as working out?”
“I actually don’t know what Ozempic is,” Kate admitted to The New York Times Magazine in an interview published in March 2024. “All I know is that it’s some pill that people are taking or something like that.”
“Oh, my God,” Kate remarked after learning about the injectable. “This sounds terrible.”
Heidi noted, “I want something that is sustainable. I want something that does also require hard work.”
“Everyone and their mom is gonna try it. Everyone has been lying saying, ‘Oh, smaller portions,'” she told Andy Cohen, who has also publicly weighed in on the Ozempic craze multiple times. “Like, shut the f–k up. You are on Ozempic or one of those things, or you got work done. Just stop.”
Schumer, who has been open about her past medical procedures, added, “Be real with people. When I got lipo, I said I got lipo.”
She admitted to becoming “immediately invested” in Ozempic in 2022, but explained that it was not “livable” for her to take the Type 2 diabetes drug as it hindered her ability to spend time with her son Gene.
“I was one of those people that felt so sick and couldn’t play with my son,” Schumer recalled. “I was so skinny, and he’s throwing a ball at me and [I couldn’t].”
View More Photos From Celebrities Speaking Out on Ozempic and Weight Loss Medications
