Coffee may help shield the liver from fat, scarring, and cancer
Date:
July 25, 2026
Source:
Cedars-Sinai Medical Center
Summary:
A major long-term study linked coffee consumption with lower risks of cirrhosis, liver cancer, and death from liver disease. Coffee drinkers also showed healthier liver scans and blood protein patterns, with less fat, inflammation, and scarring. Benefits appeared even at one or two cups daily and were strongest around three to four cups.
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FULL STORY
One of the largest investigations yet into coffee and liver health has found that people who drink more coffee tend to have lower risks of cirrhosis, liver cancer, and death related to liver disease
The Cedars-Sinai Health Sciences University study, published in Clinical Gastroenterology and Hepatology, also uncovered biological patterns that could help explain why coffee consumption has repeatedly been associated with healthier livers
“Previous studies suggested that coffee might benefit the liver, but most were smaller or looked at only one piece of the puzzle,” said hepatologist Hyunseok Kim, MD, MPH, PhD, assistant professor of Medicine at Cedars-Sinai and corresponding author of the study. “We followed hundreds of thousands of people for more than a decade and looked at their health outcomes along with liver MRI scans and blood protein analyses. Together, those findings help explain the biological mechanisms behind coffee’s association with better liver health.”
Study Followed Nearly 355,000 Adults
Researchers examined data from 354,957 UK Biobank participants who had no history of cirrhosis or liver cancer when the study began. Using linked medical records, the team tracked new cases of cirrhosis, liver cancer, and liver-related death over a median period of 13 years
The results showed that coffee drinkers generally experienced better liver outcomes than people who did not drink coffee
Participants who consumed five or more cups per day had a 32% lower risk of cirrhosis, a 47% lower risk of liver cancer, and a 42% lower risk of dying from liver disease compared with non-coffee drinkers
Coffee Linked to Less Liver Damage
The researchers also examined liver MRI scans and blood protein measurements to look for physical and molecular signs of liver health
People who drank more coffee had lower levels of liver fat, excess liver iron, fibrosis, and liver inflammation on MRI scans. Their blood samples also contained higher levels of proteins associated with healthy liver function and lower levels of proteins connected to inflammation and tissue scarring
Together, these findings provide biological support for the long-observed relationship between coffee consumption and lower liver disease risk
Although risk generally declined as coffee intake increased, the researchers found signs of benefit even among people who drank only one or two cups per day. The strongest associations appeared at about three to four cups daily
The researchers stressed that although the group consuming the most coffee (five or more cups daily) also showed benefits, they are not advising people to raise their intake specifically to that amount
Decaf Showed Similar Associations
Both caffeinated and decaffeinated coffee were linked to better liver outcomes. This suggests that caffeine is probably not the only substance responsible for the association
Coffee contains numerous naturally occurring compounds, some of which may influence inflammation, liver scarring, and other biological processes involved in liver disease
However, the study was observational. It identified associations but cannot establish that coffee directly prevents cirrhosis, liver cancer, or liver-related death
The researchers also emphasized that drinking coffee should complement, not replace, well-established approaches to protecting liver health
“Our findings support moderate coffee consumption for people who already enjoy and tolerate it well,” said study senior author Ju Dong Yang, MD, medical director of the Liver Cancer Program at Cedars-Sinai
“However, we would not recommend that someone begin drinking coffee solely for liver protection based on this study alone. Prevention should continue to focus on maintaining a healthy weight, limiting alcohol, exercising regularly, and managing blood sugar, blood pressure and cholesterol.”
Coffee Is Not Appropriate for Everyone
Caffeine may not be suitable for some people. Those with uncontrolled high blood pressure, certain heart rhythm disorders, severe anxiety, insomnia, or other conditions that require caffeine restriction should speak with a healthcare provider before increasing their coffee intake
Future research will focus on identifying which substances in coffee may be responsible for the liver-related associations observed in the study
“The next step in our research is to identify the specific compounds in coffee that are responsible for these liver-protective associations,” said study author Shelly Lu, MD, the Women’s Guild Chair in Gastroenterology and director of the Karsh Division of Gastroenterology and Hepatology at Cedars-Sinai. “Our findings point to biological pathways involving inflammation and scarring and highlight molecular targets that future research can explore to better understand how coffee may influence liver health and who stands to benefit the most.”
Additional Cedars-Sinai authors include Yufeng Wang, Abdelrahman M. Attia, Minsun Kwak, Seungwon Burm, Derin Celtik, Daniel Legaspi, Osama Khattab, Naomy Kim, Beza M. Mengistu, Kelsey N. Larios, Walid Ayoub, Alexandar Kuo, Paul Martin, Aarshi Vipani, Yun Wang, Debiao Li and Stephen Pandol
Other authors include Mohammad Saeid Rezaee-Zavareh, David Sooik Kim and Suthat Liangpunsakul
Conflicts of Interest: Ju Dong Yang reports the following conflicts of interest: consulting service for AstraZeneca, Eisai, Exact Sciences, and Fujifilm Medical Sciences
Materials provided by Cedars-Sinai Medical Center. Original Note: Content may be edited for style and length
Journal Reference:
- Hyun-Seok Kim, Mohammad Saeid Rezaee-Zavareh, Yufeng Wang, Abdelrahman M. Attia, Minsun Kwak, Seungwon Burm, Derin Celtik, Daniel Legaspi, Osama Khattab, Naomy Kim, Beza M. Mengistu, Kelsey N. Larios, David Sooik Kim, Walid Ayoub, Alexandar Kuo, Paul Martin, Aarshi Vipani, Yun Wang, Suthat Liangpunsakul, Debiao Li, Shelly C. Lu, Stephen Pandol, Ju Dong Yang. Coffee Consumption and Improved Liver Outcomes: Clinical, Imaging, and Proteomic Evidence From the UK Biobank. Clinical Gastroenterology and Hepatology, 2026; DOI: 10.1016/j.cgh.2026.04.035
Cite This Page:
Cedars-Sinai Medical Center. “Coffee may help shield the liver from fat, scarring, and cancer.” ScienceDaily. ScienceDaily, 25 July 2026. <www.sciencedaily.com/releases/2026/07/260719035955.htm>.
Cedars-Sinai Medical Center. (2026, July 25). Coffee may help shield the liver from fat, scarring, and cancer. ScienceDaily. Retrieved July 25, 2026 from www.sciencedaily.com/releases/2026/07/260719035955.htm
Cedars-Sinai Medical Center. “Coffee may help shield the liver from fat, scarring, and cancer.” ScienceDaily. www.sciencedaily.com/releases/2026/07/260719035955.htm (accessed July 25, 2026).
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