Pfizer’s Next Weight-Loss Weapon: How Berobenatide Stacks Up Against Novo Nordisk’s Wegovy and Eli Lilly’s Zepbound
Prosper Junior Bakiny, The Motley Fool
Sat, August 8, 2026 at 1:18 AM GMT+5:30
5 min read
The past few years have been rough on Pfizer (NYSE: PFE). The company has generally posted subpar financial results due to weakness within its coronavirus franchise, which once helped it become the first biopharmaceutical company to achieve $100 billion in annual sales. The drugmaker is looking to turn things around by developing potential blockbuster products, and one of its most promising candidates is berobenatide, an investigational weight loss therapy. The anti-obesity market is growing rapidly and could be worth $190 billion by 2035, compared to just $79 billion last year, according to some estimates. Could Pfizer’s berobenatide help the company capitalize on this large opportunity?
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Challenging the giants
Pfizer will have to compete against the leaders in the weight-loss market, Eli Lilly, whose Zepbound is the best-selling drug in this niche, and Novo Nordisk, a pioneer in the market and the company behind Wegovy, perhaps the best-known brand in the field. How does berobenatide compare to Wegovy and Zepbound? It’s hard to say without head-to-head clinical trials, but the data we do have so far suggest that Pfizer’s candidate could be highly competitive
In a phase 2b study, berobenatide achieved a weight loss of almost 16% (non-placebo-adjusted) in 32 weeks, with no plateau observed. Those are strong results, considering that Zepbound posted a weight loss of 20.2%, versus Wegovy’s 13.7%, in a 72-week head-to-head study. If berobenatide can extend its results in phase 3 studies, we could be looking at the next billion-dollar weight loss drug
The case for Pfizer
Berobenatide has another advantage: It could be administered monthly. So, even with slightly lower efficacy than weekly anti-obesity medicines, it may attract a large patient population. Further, the medicine’s safety and tolerability profile appears strong. Pfizer is planning to run various phase 3 studies for this candidate across weight management and obesity-related comorbidities, including such potential indications as obstructive sleep apnea and knee osteoarthritis. This is clearly a highly promising product, and it seems the market has yet to factor its potential into Pfizer’s share price.
The stock has basically moved sideways since November, when Pfizer acquired Metsera, the biotech company that originally developed berobenatide. It’s also worth noting that Pfizer has plenty of other attractive candidates, especially in oncology. Also, even though its financial results haven’t been strong, some of the company’s products should perform well over the medium term. The list includes Padcev, a cancer medicine. Then there is Pfizer’s strong dividend program. The company regularly increases its payouts and currently offers a juicy forward yield of 6.7%. All of those are great reasons to consider the stock.
