Browsing: Distinct

Overreactions to ordinary sensory stimuli — a scratchy shirt tag, a roaring vacuum cleaner, an unfamiliar smell — are commonly associated with autism. But in fact, an estimated 15% to 20% of children experience such reactions, known as sensory over-responsivity or sensory distress, and they show up across a range of psychiatric conditions

The development of dual agonists for the glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) has been a landmark moment in the treatment of type 2 diabetes and obesity. However, for reasons that are incompletely understood, in preclinical and clinical studies, adding either a GIPR agonist or GIPR antagonist to GLP-1R agonism causes…