Browsing: perineurium

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The perineurium integrates leptin with its sympathetic outflow to protect against obesity

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The regulatory mechanism of leptin’s afferent action in the brain is contingent upon the efferent sympathetic innervation of white and brown adipose tissues. Nonetheless, the peripheral regulation governing the afferent–efferent balance remains ambiguous. Here we show the enriched expression of both leptin receptor (Lepr) and β2-adrenergic receptor (Adrb2) in perineurial cells that form a barrier…