Abstract
The Singapore National Precision Medicine (NPM) program is a three-phase whole-of-nation effort designed to develop scalable, evidence-based solutions for precision health tailored to Asia’s diverse populations. Here we present NPM phase II (2020–2025), highlighting how large-scale precision medicine initiatives can drive new research insights, enable healthcare innovations and create economic value. Key achievements include the PRECISE-SG100K population dataset, which reflects Singapore’s unique multi-ancestry Asian population; the successful translation of research findings into mainstream national healthcare using familial hypercholesterolemia as a use case; and the establishment of strategic public–private partnerships with diverse industry sectors. We also outline phase III (2025–2031), which aims to establish whole-genome sequencing as a foundational element of a patient’s lifelong healthcare record for 10% of the population. NPM provides a model for how smaller countries, despite limited populations and finite resources, can contribute meaningfully to global scientific movements while preserving strategic independence and addressing national health challenges.
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Acknowledgements
Work conducted under phase II of the National Precision Medicine (NPM) program is supported by the National Research Foundation, Singapore (NRF), through RIE2020 White Space funding (MOH-000588 and MOH-001264), administered by the Singapore Ministry of Health (MOH) through the National Medical Research Council Office (NMRCO), MOH Holdings Pte Ltd. NPM phase III is supported by the MOH through the NMRCO under the NMRC RIE2025 NPM Phase III Funding Initiative (MOH-001734). Support related to SG100K (NTU IRB: 2016-11-030) is provided by the NMRCO under its OF-LCG funding scheme (MOH-000271 and MOH-001792), by the NMRC through the National Cohorts Office (P2022-02-03) and by NPM. We also acknowledge institutional support from Nanyang Technological University, Lee Kong Chian School of Medicine and National Healthcare Group (HELIOS), the NMRCO, the Biomedical Research Council, MOH Population Health Metrics and Analytics, National University of Singapore and National University Health System Singapore (SPHS, Preemptive Pharmacogenomics), SingHealth, Duke-NUS (SingHEART, PRISM), the NMRCO Centre Grant to National Heart Centre Singapore (CGAug16M006, NMRC/CG1/003/2021-NHCS), Genome Institute of Singapore (A*STAR) and Khoo Teck Puat Hospital. We extend our gratitude to all study participants for their time, commitment and invaluable contributions to advancing precision medicine research in Singapore. We acknowledge the support provided by the TRUST (Trusted Research and Real-World Data Utilization and Sharing Tech) platform, Singapore MOH. We thank MOH Holdings and Singapore’s three healthcare clusters (NHG Health, National University Health System and SingHealth) for facilitating participant recruitment and providing operational support. We acknowledge A*STAR’s Genome Institute of Singapore, NovogeneAIT Genomics and Illumina for their sequencing operations under the PRECISE public–private partnership. We thank the Science Centre Singapore for hosting public exhibitions and the Temasek Foundation, the Lee Foundation and the family of H.H.L. Kwee for philanthropic support. We further acknowledge the PRECISE Scientific Advisory Board and the PRECISE Board Oversight Committee for their strategic guidance and oversight throughout the NPM program. We acknowledge the individual contributions of the site principal investigators and co-investigators, whose leadership and coordination enabled participant recruitment and the successful implementation of PRECISE’s clinical implementation pilots. We thank the PRECISE-SG100K operations teams for their dedication to participant recruitment, organization, and data and sample collection. The views expressed are those of the authors and do not reflect the positions of the Singapore MOH or the NRF.
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Author notes
These authors contributed equally: Shih Wee Seow, Theresia Mina
Authors and Affiliations
Precision Health Research, Singapore (PRECISE), Singapore, Singapore
Shih Wee Seow, Clement Qiwen Sin, Denise Xin Yi Chua, Emily Shu Fang Lau, Gloria Hoi Wan Tso, Huiping Huang, Janice Sin Hong Natalie Chong, Jasmine Kah Bing Tan, Jia En Tan, Li Harn Leong, Nichole Choon Ya Lim, Nicole Ziyi Zhuo, Yaelim Lee, Yun Keng Pang, Kriti Sethi, Doreen Low, Irenaeus Paul Chia, Weiling Zheng, Ee Shien Tan, Max Lam, E. Shyong Tai, John Chambers & Patrick Tan
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
Theresia Mina, Nilanjana Sadhu, Pritesh Jain, Xiaoyan Wang, Joanne Ngeow, Akash Bahai, Darwin Tay, Dorrain Yanwen Low, Elio Riboli, Eng Sing Lee, Gervais Wansaicheong, He Wang, Hong Kiat Ng, Marie Loh, Paul Elliott, Rinkoo Dalan, Terry Yoke Yin Tong, Tock Han Lim, Yik Weng Yew, Alvin Ng, Claresta Yeo, George Arun Devasia, Isaac Zhenhan Lin, Jens Samol, Nur Hikmah Fitriyah Binte Mohammad Rafiz, Sangeetha Shanmugam, Sara Tasnim, Siao Ting Chong, Zhi Yi Koo, Jimmy Lee, Sabrina Wong, Max Lam & John Chambers
Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
Maxime Hebrard, Claire Bellis, Bitong Clarabelle Alexandrine Lin, Pierre Vincent-Goy, Jingmei Li, Amelia Sutikna, Erin Yi Ting Lin, Joanna Hui Juan Tan, Justin Jeyakani, Khai Koon Heng, Jack Ling Ow, Paul Chung Pui Cheng, Rodrigo Toro Jimenez, Shakita Sunmugam, Shimin Ang, Tat Hung Koh, Wee Yang Meah, Xiao Yin Chen, Zhicheng Xie, Zhihui Li, Peh Joo Ho, Eleanor Wong, Chiea Chuen Khor, Nicolas Bertin & Patrick Tan
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
Maxime Hebrard
Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia
Claire Bellis
RIE TRUST Office, Singapore, Singapore
Pin Yan Low, Danny Ong, Kevin Lam, Mervin Chan, Yu Li Ng, Zhen Xuan Yeo & Mingshi Koh
Diabetes Centre, Admiralty Medical Centre, Singapore, Singapore
Tavintharan Subramaniam
Clinical Research Unit, Khoo Teck Puat Hospital, Singapore, Singapore
Tavintharan Subramaniam & Sharon Pek
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore
Hwee Lin Wee, Alec Morton, Yi Wang, Mikael Hartman, Charlie Guan Yi Lim, Jiali Yao, Linda Wei Lin Tan, Rob M. van Dam, Peh Joo Ho & Xueling Sim
Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore
Joanne Ngeow, Andrea Tan Wan Ling, Caitlin Nicole Samy Victoria, Diya Porwal, Ee Ling Chew, Janeshi Ashwini Wijeweera, Jeanette Yuen, Jianbang Chiang, Jieru Ye, Manasadevi Karthikeyan, Rebecca Caeser, Ruby Clarissa Sutopo, Sarah Shahrin, Serene Jianglei Wu, Shao-Tzu Li, Tasmyn Dale Scriven, Tiffany Qing Lim, Vanna Chhay & Zewen Zhang
Oncology Academic Clinical Program, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore
Joanne Ngeow & Rebecca Caeser
Erasmus School of Health Policy and Management, Erasmus University Rotterdam, Rotterdam, Netherlands
Ken Redekop
Duke-NUS Medical School, National University of Singapore, Singapore, Singapore
Alec Morton, Wei Ting Huang, Jonathan Jiunn Liang Yap, Saumya Jamuar, Khung Keong Yeo, Ee Shien Tan, E. Shyong Tai & Patrick Tan
Department of Management Science, University of Strathclyde, Glasgow, UK
Alec Morton
Department of Paediatrics, National University of Singapore, Singapore, Singapore
Kar Hui Ng, Hui-Lin Chin, Hui Kim Yap, Jun Li Ng, Mya Than & Yaochun Zhang
Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, Singapore, Singapore
Kar Hui Ng, David Lu, Sharon Teo & Perry Lau
Department of Medicine (General Internal Medicine), Duke University School of Medicine, Durham, NC, USA
David Matchar
Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore
David Matchar & Naline Gandhi
Department of Surgery, National University Hospital, National University Health System, Singapore, Singapore
Mikael Hartman
Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore
Mikael Hartman, Jingmei Li, Peh Joo Ho & Su-Ann Goh
National Cancer Centre Singapore, Singapore Health Services (SingHealth), Singapore, Singapore
Jingmei Li
Department of Pharmacy, National University Hospital, Singapore, Singapore
Elaine Ah Gi Lo, Hui Min Chua & Ken Juin Lim
Department of Cardiology, National Heart Centre Singapore, Singapore, Singapore
Wei Ting Huang, Annie Lee, Jonathan Jiunn Liang Yap, Siew Ching Kong, Eric Tien Siang Lim, Ju Le Tan, Terrence Chua & Khung Keong Yeo
SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore
Jane Andrea Lie Bylstra, Weng Khong Lim & Saumya Jamuar
Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore
Jane Andrea Lie
SingHealth Duke-NUS Genomic Medicine Centre, Singapore, Singapore
Weng Khong Lim
Laboratory of Genome Variation Analytics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
Weng Khong Lim
Genetics Service, Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore, Singapore
Saumya Jamuar & Ee Shien Tan
Diagnostics Development Hub (DxD Hub), Agency for Science, Technology and Research, Singapore, Singapore
Ruifen Weng
Centre for Biomedical Ethics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Angela Ballantyne, Hui Jin Toh, Owen Schaefer, Serene Ong, Marthe Smedinga & Tamra Lysaght
Sydney Health Ethics, Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia
Tamra Lysaght
North Region, Institute of Mental Health, Singapore, Singapore
Jimmy Lee & Max Lam
National Healthcare Group Polyclinics, Singapore, Singapore
Tricia Chang, Wai Kee Kok & Sabrina Wong
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
Can Can Xue, Miao Ling Chee, Miao Li Chee, Tin Aung, Tien Yin Wong, Yih Chung Tham, Zhi Da Soh, Ching-Yu Cheng & Charumathi Sabanayagam
Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Yih Chung Tham & Ching-Yu Cheng
Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore
Tin Aung & Charumathi Sabanayagam
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Soo Chin Lee & Boon Cher Goh
Department of Haematology-Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore
Soo Chin Lee, Pei Yi Ong, Samuel G. W. Ow & Boon Cher Goh
Department of Medicine, National University Hospital, Singapore, Singapore
Boon Cher Goh
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Boon Cher Goh
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
E. Shyong Tai
Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK
Elio Riboli, Harinakshi Sanikini, Kostas Tsilidis, Paul Elliott & John Chambers
Khoo Teck Puat Hospital, Singapore, Singapore
Benjamin Chih Chiang Lam
MOH Office for Healthcare Transformation, Singapore, Singapore
Eng Sing Lee
Department of Diagnostic Radiology, Tan Tock Seng Hospital, Singapore, Singapore
Gervais Wansaicheong
Department of Ophthalmology, Tan Tock Seng Hospital, Singapore, Singapore
Kelvin Li & Tock Han Lim
Research Division, National Skin Centre, Singapore, Singapore
Marie Loh & Yik Weng Yew
Department of Endocrinology, Tan Tock Seng Hospital, Singapore, Singapore
Rinkoo Dalan & Rinkoo Dalan
Departments of Exercise and Nutrition Sciences and Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, DC, USA
Rob M. van Dam
Tsinghua Medicine, Tsinghua University, Beijing, China
Tien Yin Wong
Beijing Visual Science and Translational Eye Research Institute (BERI), Eye Center of Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China
Tien Yin Wong
Office of Research, Duke-NUS Medical School, Singapore, Singapore
Nellie Bin Siew Chai
Asian Centre for Health Behavioural Insights and Interventions (HABITS), Nanyang Technological University, Singapore, Singapore
Anita Sheldenkar, Jo-Anne Manski-Nankervis, May Lwin & Zoe Ong
Wee Kim Wee School of Communication and Information, Nanyang Technological University, Singapore, Singapore
Jack Yong Ho, Jo-Anne Manski-Nankervis, May Lwin & Zoe Ong
Department of Primary Health Care and General Practice, University of Otago, Wellington, New Zealand
Angela Ballantyne
Biomedical Sciences Industry Partnership Office, Agency for Science, Technology and Research, Singapore, Singapore
Yee Kwang Seck
Division of Economics, School of Social Sciences, Nanyang Technological University, Singapore, Singapore
Akshar Saxena
Equitech, Singapore, Singapore
Chi Ling Chan
University of California, San Francisco, San Francisco, CA, USA
Chi Ling Chan
University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Chi Ling Chan
Personalized Medicine Service, Tan Tock Seng Hospital, Singapore, Singapore
Chia Wei Lim & Dana Leng Hui Chan
Johns Hopkins University, Baltimore, MD, USA
Jens Samol
Department of Medical Oncology, Tan Tock Seng Hospital, Singapore, Singapore
Jens Samol & Valerie Yue Ming Heong
Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
Soo Chin Lee
National Cancer Centre Singapore, Singapore, Singapore
Nur Diana Binte Ishak & Zewen Zhang
National University Cancer Institute, Singapore, Singapore
Pei Yi Ong
National University Hospital, Singapore, Singapore
Pei Yi Ong
Department of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore
Rutharra Ghayadthri Manisekaran
Department of Medicine (Nephrology), National University Hospital, Singapore, Singapore
Boon Wee Teo, Gek Cher Chan & Yi Da
Department of Paediatrics (Genetics), KK Women’s and Children’s Hospital, Singapore, Singapore
Breana Cham, Jiin Ying Lim, Jeannette Goh & Syl
Department of Paediatrics (Nephrology), KK Women’s and Children’s Hospital, Singapore, Singapore
Celeste Jia Ying Yap, Esther Huimin Leow, Yong Hong Ng, Indra Ganesan, Siew Le Chong & Sing Ming Chao
Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore
Cynthia Ciwei Lim, Jason C. J. Choo, Irene Mok, Hui Zhuan Tan, Tung Lin Lee & Jia Liang Kwek
SingHealth Duke-NUS Academic Medical Center, Singapore, Singapore
Cynthia Ciwei Lim
Department of Renal Medicine, Tan Tock Seng Hospital, Singapore, Singapore
Ru Sin Lim, Regina Shaoying Lim, See Cheng Yeo & Su Mein Goh
KK Research Center, KK Women’s and Children’s Hospital, Singapore, Singapore
Jing Yi Ho
Medicine Academic Clinical Programme, Singapore General Hospital, Singapore, Singapore
Kay Yuan Chong
Clinical Research and Innovation Office, Tan Tock Seng Hospital, Singapore, Singapore
Ziyin Wang
Jurong Polyclinic, National University Polyclinics and National University Health System, Singapore, Singapore
Chi Hui Chin & Desmond Luan Seng Ong
Department of General Surgery, Ng Teng Fong General Hospital, Singapore, Singapore
Han Boon Oh & Philip Choong Tsau Iau
Department of General Surgery, Jurong Medical Centre, Singapore, Singapore
Han Boon Oh
Department of Surgery, National University Hospital and National University Health System, Singapore, Singapore
Philip Choong Tsau Iau & Sujith Wijerathne
Department of Diagnostic Imaging, National University Hospital and National University Health System, Singapore, Singapore
Pooja Jagmohan
Bukit Batok Polyclinic, National University Polyclinics and National University Health System, Singapore, Singapore
Sing Cheer Kwek
Department of Surgery, Alexandra Hospital and National University Health System, Singapore, Singapore
Sujith Wijerathne
Choa Chu Kang Polyclinic, National University Polyclinics and National University Health System, Singapore, Singapore
Zhi Peng Zhang
Department of Cardiology, National University Heart Centre Singapore, Singapore, Singapore
Chester Drum
Department of Paediatric Endocrinology, KK Women’s and Children’s Hospital, Singapore, Singapore
Fabian Yap
Department of Medicine, Alexandra Hospital, Singapore, Singapore
Fathima Ashna Nastar
Department of Endocrinology, Singapore General Hospital, Singapore, Singapore
Hong Chang Tan
NHG Ang Mo Kio Polyclinic, Singapore, Singapore
Ian Jan Ming Koh
Health Psychology/Behavioural Medicine, Lee Kong Chian School of Medicine, Singapore, Singapore
Konstadina Griva
Department of Cardiology, Sengkang General Hospital, Singapore, Singapore
Natalie Si Ya Koh
Department of Cardiology, Tan Tock Seng Hospital, Singapore, Singapore
Quek Wei Yeong
Department of General Medicine, Khoo Teck Puat Hospital, Singapore, Singapore
Sanjaya Dissanayake & Teck Choon Tan
Department of Endocrinology, Changi General Hospital, Singapore, Singapore
Wann Jia Loh
Department of Medicine, Ng Teng Fong General Hospital, Singapore, Singapore
Yee Sian Tiong
National University Health System Pharmacy, Singapore, Singapore
Amanda Lay Ying Lim
Division of Neurology, Department of Medicine, National University Hospital, Singapore, Singapore
Benjamin Yong-Qiang Tan
Division of Pharmacy, Tan Tock Seng Hospital, Singapore, Singapore
Christina Jiun Yu Tan
Department of Pharmacy, Ng Teng Fong General Hospital, Singapore, Singapore
Dennis Chua, Evelyn Shi Jie Tan & Huang En Toh
Department of Pharmacy, Alexandra Hospital, Singapore, Singapore
Golda Wang & Min Yi Gwee
Department of Intensive Care Medicine, Department of Medicine, Ng Teng Fong General Hospital, Singapore, Singapore
Jared D’Souza
Department of Pharmacy, Khoo Teck Puat Hospital, Singapore, Singapore
Jing Wen Oh & Siok Ying Lee
Department of Group Medical Informatics Office, National University Health System, Singapore, Singapore
Jishana Farhad
Department of Neurology (Singapore General Hospital Campus), National Neuroscience Institute, Singapore, Singapore
Kaavya Narasimhalu
Division of Biomedical Informatics, Department of Surgery, National University of Singapore, Singapore, Singapore
Kee Yuan Ngiam
Centre for Precision and Genomic Medicine, Tan Tock Seng Hospital, Singapore, Singapore
Khai Pang Leong
Molecular Diagnostic Laboratory, Tan Tock Seng Hospital, Singapore, Singapore
Liuh Ling Goh
Division of Pharmacy, Singapore General Hospital, Singapore, Singapore
Pei Shieen Wong
Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, Singapore, Singapore
Pei Shieen Wong
National University Polyclinics, Singapore, Singapore
Rangpa Taiju
Department of Psychiatry, Ng Teng Fong General Hospital, Singapore, Singapore
Yi Min Wan
Authors
- Shih Wee SeowView author publications
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- Theresia MinaView author publications
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- Maxime HebrardView author publications
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- Elaine Ah Gi LoView author publications
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Consortia
PRECISE-SG100K Consortium
- Precision Health Research, Singapore (PRECISE)
- , Clement Qiwen Sin
- , Denise Xin Yi Chua
- , Emily Shu Fang Lau
- , Gloria Hoi Wan Tso
- , Huiping Huang
- , Janice Sin Hong Natalie Chong
- , Jasmine Kah Bing Tan
- , Jia En Tan
- , Li Harn Leong
- , Nichole Choon Ya Lim
- , Nicole Ziyi Zhuo
- , Yaelim Lee
- & Yun Keng Pang
SG100K Longitudinal Population Study Partners: Health for Life in Singapore (HELIOS) Study
- Akash Bahai
- , Benjamin Chih Chiang Lam
- , Darwin Tay
- , Dorrain Yanwen Low
- , Elio Riboli
- , Eng Sing Lee
- , Harinakshi Sanikini
- , Gervais Wansaicheong
- , He Wang
- , Hong Kiat Ng
- , Kelvin Li
- , Kostas Tsilidis
- , Marie Loh
- , Paul Elliott
- , Rinkoo Dalan
- , Terry Yoke Yin Tong
- , Tock Han Lim
- , Tricia Chang
- , Wai Kee Kok
- & Yik Weng Yew
School of Population Health Studies
- Linda Wei Lin Tan
- & Rob M. van Dam
Singapore Epidemiology of Eye Diseases Study (SEED)
- Can Can Xue
- , Miao Ling Chee
- , Miao Li Chee
- , Tin Aung
- , Tien Yin Wong
- , Yih Chung Tham
- , Zhi Da Soh
- , Annie Lee
- , Jonathan Jiunn Liang Yap
- & Siew Ching Kong
Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore
- Amelia Sutikna
- , Erin Yi Ting Lin
- , Joanna Hui Juan Tan
- , Justin Jeyakani
- , Khai Koon Heng
- , Jack Ling Ow
- , Paul Chung Pui Cheng
- , Rodrigo Toro Jimenez
- , Shakita Sunmugam
- , Shimin Ang
- , Tat Hung Koh
- , Wee Yang Meah
- , Xiao Yin Chen
- , Zhicheng Xie
- & Zhihui Li
SingHealth Duke-NUS Institute of Precision Medicine, Singapore
- Jane Andrea Lieviant
- , Jing Xian Teo
- , Nellie Bin Siew Chai
- & Wan Wan Lim
RIE TRUST Office
- Danny Ong
- , Kevin Lam
- , Mervin Chan
- , Yu Li Ng
- & Zhen Xuan Yeo
Wee Kim Wee School of Communication and Information, Asian Centre for Health Behavioural Insights and Interventions (HABITS), Nanyang Technological University, Singapore
- Anita Sheldenkar
- , Jack Yong Ho
- , Jo-Anne Manski-Nankervis
- , May Lwin
- & Zoe Ong
Centre for Biomedical Ethics, Yong Loo Lin School of Medicine, National University, Singapore
- Angela Ballantyne
- , Hui Jin Toh
- , Owen Schaefer
- & Serene Ong
Biomedical Sciences Industry Partnership Office
- Yee Kwang Seck
PRECISE-CIP Consortium
Hereditary Cancer
- Akshar Saxena
- , Alvin Ng
- , Andrea Tan Wan Ling
- , Caitlin Nicole Samy Victoria
- , Chi Ling Chan
- , Chia Wei Lim
- , Claresta Yeo
- , Dana Leng Hui Chan
- , Diya Porwal
- , Ee Ling Chew
- , George Arun Devasia
- , Isaac Zhenhan Lin
- , Janeshi Ashwini Wijeweera
- , Jeanette Yuen
- , Jens Samol
- , Jianbang Chiang
- , Jieru Ye
- , Soo Chin Lee
- , Manasadevi Karthikeyan
- , Nikita Bora
- , Nur Diana Binte Ishak
- , Nur Hikmah Fitriyah Binte Mohammad Rafiz
- , Pei Yi Ong
- , Rebecca Caeser
- , Ruby Clarissa Sutopo
- , Rutharra Ghayadthri Manisekaran
- , Samuel G. W. Ow
- , Sangeetha Shanmugam
- , Sara Tasnim
- , Sarah Shahrin
- , Serene Jianglei Wu
- , Shao-Tzu Li
- , Siao Ting Chong
- , Tasmyn Dale Scriven
- , Tiffany Qing Lim
- , Valerie Yue Ming Heong
- , Vanna Chhay
- , Zewen Zhang
- & Zhi Yi Koo
Renal Alliance for Precision Diagnosis in Singapore (RAPIDS)
- Boon Wee Teo
- , Breana Cham
- , Celeste Jia Ying Yap
- , Cynthia Ciwei Lim
- , David Lu
- , Esther Huimin Leow
- , Hui-Lin Chin
- , Jason C. J. Choo
- , Ru Sin Lim
- , Gek Cher Chan
- , Yi Da
- , Hui Kim Yap
- , Irene Mok
- , Jiin Ying Lim
- , Jing Yi Ho
- , Sharon Teo
- , Perry Lau
- , Hui Zhuan Tan
- , Tung Lin Lee
- , Yong Hong Ng
- , Indra Ganesan
- , Siew Le Chong
- , Sing Ming Chao
- , Jeannette Goh
- , Jia Liang Kwek
- , Jun Li Ng
- , Kay Yuan Chong
- , Mya Than
- , Naline Gandhi
- , Regina Shaoying Lim
- , See Cheng Yeo
- , Su Mein Goh
- , Sylvia Kam
- , Yaochun Zhang
- & Ziyin Wang
Breast Screening Tailored for Her (BREATHE)
- Chi Hui Chin
- , Desmond Luan Seng Ong
- , Han Boon Oh
- , Peh Joo Ho
- , Philip Choong Tsau Iau
- , Pooja Jagmohan
- , Sing Cheer Kwek
- , Su-Ann Goh
- , Sujith Wijerathne
- & Zhi Peng Zhang
FHCARE
- Chester Drum
- , Eric Tien Siang Lim
- , Fabian Yap
- , Fathima Ashna Nastar
- , Hong Chang Tan
- , Ian Jan Ming Koh
- , Ju Le Tan
- , Konstadina Griva
- , Natalie Si Ya Koh
- , Quek Wei Yeong
- , Rinkoo Dalan
- , Sanjaya Dissanayake
- , Terrence Chua
- , Wann Jia Loh
- & Yee Sian Tiong
Preemptive Pharmacogenomic Testing
- Amanda Lay Ying Lim
- , Benjamin Yong-Qiang Tan
- , Christina Jiun Yu Tan
- , Dennis Chua
- , Evelyn Shi Jie Tan
- , Golda Wang
- , Huang En Toh
- , Hui Min Chua
- , Jared D’Souza
- , Jing Wen Oh
- , Jishana Farhad
- , Kaavya Narasimhalu
- , Kee Yuan Ngiam
- , Ken Juin Lim
- , Khai Pang Leong
- , Liuh Ling Goh
- , Min Yi Gwee
- , Pei Shieen Wong
- , Rangpa Taiju
- , Siok Ying Lee
- , Teck Choon Tan
- , Yi Min Wan
- & Zewen Zhang
Contributions
P.T., J.C. and E. S. Tai conceived the overall program strategy and provided overarching scientific and implementation leadership. E. S. Tai and E. S. Tan led clinical activities across phase II CIPs. M.L. led data curation and the development of the national genomic research resource enabling large-scale analyses and clinical translation. J.C., X.S., K.K.Y. and C.-Y.C. conceived the SG100K population study and led its delivery at their respective institutions. T.M. led the phenotypic data analysis, supported genotype–phenotype correlation studies across cohorts and contributed to manuscript writing. S.W.S. oversaw manuscript writing, program-wide operational planning, implementation coordination and national-level integration. J.N., K.R. and A.M. co-led the clinical translation and implementation of the Hereditary Cancer Clinical Implementation Pilot (CIP). T.S., S.P. and H.L.W. co-led the FHCARE CIP, while H.L.W., E.A.G.L. and B.C.G. co-led the Pharmacogenomics CIP. K.H.N. and D.M. co-led the RAPIDS CIP. Y.W., M. Hartman and J. Li co-led the BREATHE CIP. K.K.Y., W.T.H., C.-Y.C., C.S., X.S., J. Lee and S.W. led recruitment and clinical phenotyping as cohort principal investigators. C.G.Y.L. and J.Y. supported participant recruitment, phenotyping and follow-up activities. T.M., N.S., P.J. and X.W. analyzed phenotypic data and supported genotype–phenotype correlation and health informatics analyses. M. Hebrard, P.V.-G. and N.B. performed genomic and statistical data analyses. P.V.-G. and N.B. developed and implemented bioinformatics workflows and analytical pipelines. C.B., B.C.A.L. and C.C.K. oversaw DNA extraction and laboratory quality procedures. R.W. supported the clinical translation of the carrier screening program through the Diagnostics Development Hub (DxD Hub). Y.B., W.K.L. and S.J. contributed to variant curation and clinical interpretation and supported the return of genomic results and genetic counseling activities. M.S. and T.L. designed and conducted empirical research on the ethical and societal dimensions of precision medicine. K.S. contributed to the development of governance and data access policies. W.Z. contributed to the conceptualization and operationalization of the Pharma Pre-Competitive Consortium (PCC). P.Y.L. and M.K. contributed to the conceptualization and operationalization of TRUST. D.L. and C.I.P. contributed to the conceptualization and operationalization of the clinical implementation pilots. E.W. supported program administration, logistics and cross-team operational coordination. All authors reviewed, edited and approved the final manuscript.
Ethics declarations
Competing interests
A.M. is a co-principal investigator on a service contract between Illumina and the Saw Swee Hock School of Public Health (SSHSPH). H.L.W. reports institutional funding and honoraria from Pfizer Singapore, Boehringer Ingelheim Singapore Pte Ltd, MSD International GmbH (Singapore Branch), MSD Pharma (Singapore) Pte Ltd, Roche Diagnostics International Ltd, Edwards Lifesciences (Asia) Pte Ltd, AstraZeneca Singapore Pte Ltd, Pfizer Private Limited, GlaxoSmithKline Pte Ltd and Takeda Pharmaceuticals (Asia Pacific) Pte Ltd. J.N. reports research funding from Illumina, PacBio, Oxford Nanopore Technologies, MSD, Nalagenetics, Lifestrands and Ambry Genetics; patient support funding from AstraZeneca and MSD; and speaker honoraria from MSD. J. Lee reports honoraria and advisory roles with Otsuka, Janssen, Lundbeck, Sumitomo Pharmaceuticals, Boehringer Ingelheim and ThoughtFull World Pte Ltd. K.K.Y. reports research funding from Amgen, AstraZeneca, Abbott, Bayer, Boston Scientific, Shockwave Medical and Novartis; consulting fees from Abbott, Amgen, Medtronic, Novartis, Peijia Medical and Novo Nordisk; speaker fees from multiple industry partners; and equity interests in Trisail and Aereus Scientific Pte Ltd. P.T. reports stock ownership in Tempus AI and Auristone Pte Ltd. W.K.L. and S.J. are co-founders of Rhea Health Pte Ltd. The other authors declare no competing interests.
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Nature Genetics thanks Sue L. Hill, Said Ismail and Zornitza Stark for their contribution to the peer review of this work
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Seow, S.W., Mina, T., Hebrard, M. et al. Translating genomic data into healthcare practice with the Singapore National Precision Medicine program.
Nat Genet (2026). https://doi.org/10.1038/s41588-026-02687-8
Received:12 January 2026
Accepted:22 June 2026
Published:29 July 2026
Version of record:29 July 2026
DOI
:https://doi.org/10.1038/s41588-026-02687-8
