The Department of Veterans Affairs is launching a nationwide clinical trial to determine whether semaglutide, marketed as Ozempic for Type 2 diabetes and Wegovy for chronic weight management, can help treat alcohol use disorder in veterans, a condition VA says has been diagnosed in more than 400,000 veterans nationwide
Semaglutide is approved by the Food and Drug Administration to treat Type 2 diabetes and chronic weight management, but not alcohol use disorder
VA researchers are studying whether the GLP-1 receptor agonist may affect parts of the brain involved in reward, potentially offering a new treatment option for veterans with moderate or severe alcohol use disorder if proven safe and effective
The department cautioned veterans not to self-medicate or replace evidence-based alcohol use disorder treatments with GLP-1 medications without first consulting a health care provider
The study, known as the Cessation or Reduction of Alcohol Consumption in Veterans (CRAVE) trial, will enroll more than 600 veterans ages 18 to 80 at 18 VA medical centers nationwide
Participants with moderate or severe alcohol use disorder will receive weekly injections of either semaglutide or a placebo for 24 weeks, followed by a safety evaluation. Researchers will measure changes in alcohol consumption, overall health and quality of life
Researchers at Washington University School of Medicine have increasingly studied whether GLP-1 medications, originally developed for diabetes and later approved for obesity, could also help treat substance use disorders
VA cited an analysis published in March that found patients taking GLP-1 medications experienced lower rates of alcohol use disorder and other substance use disorders than similar patients taking other diabetes medications
The department said larger, controlled clinical trials are needed to determine whether semaglutide is safe and effective for treating alcohol use disorder
In an official statement, VA Secretary Doug Collins said, “By exploring emerging treatment options like the use of a GLP-1 for AUD, we aim to expand the tools available to help Veterans take control of their health and recovery.”
Recruitment began July 28. Veterans interested in participating can contact their local VA medical center or search for the trial on ClinicalTrials.gov
In Other News
US industrial base is becoming stronger for wartime production, <a href="https://healthylife7.com/cattle-make-up-most-of-california-wolves-diet-uc-davis-study-finds/” title=”Cattle make up most of California wolves' diet, UC Davis study finds”>study finds
As recent conflicts consume weapons at a ferocious rate, America’s defense industrial base is becoming more prepared to sustain a major war.
How veterans groups came to clash over a sweeping VA benefits bill
Veterans organizations are deeply divided over details contained in the sweeping legislation known as the Taking Care of America’s Veterans Act.
GOP lawmakers seek review of VFW’s claims authority amid veterans cartoon controversy
The inquiry follows the VFW’s use of a “firing squad” cartoon to support preserving veterans benefits.
Pentagon to explore cheaper replacements for the MQ-9 Reaper
The Massed Modular Aircraft project aims to develop a drone that can operate in such large numbers that it can absorb losses and still overwhelm defenses.
Load More
